| Date | Day | Opponent | Location | TV | Outcome/Time |
| 08/31/2000 | Thu | Appalachian State | Winston-Salem, N.C. | | L, 20-16
Recap | Stats | Notes |
| 09/09/2000 | Sat | North Carolina | Winston-Salem, N.C. | | L, 35-14
Recap | Stats | Notes |
| 09/16/2000 | Sat | Clemson | Clemson, S.C. | | L, 55-7
Recap | Stats | FANSlive GameTracker |
| 09/30/2000 | Sat | Virginia | Winston-Salem, N.C. | | L, 27-10
Recap | Stats | Notes |
| 10/07/2000 | Sat | Vanderbilt | Winston-Salem, N.C. | | L, 17-10
Recap | Stats | Notes |
| 10/14/2000 | Sat | Georgia Tech | Atlanta | | L, 52-20
Recap | Stats | Notes |
| 10/21/2000 | Sat | Maryland | College Park, Md. | | L, 37-7
Recap | Stats |
| 11/04/2000 | Sat | Duke | Winston-Salem, N.C. | Jefferson Pilot | W, 28-26
Recap | Stats |
| 11/11/2000 | Sat | Florida State | Winston-Salem, N.C. | | L, 35-6
Recap | Stats |
| 11/18/2000 | Sat | Navy | Annapolis, Md. | | W, 49-26
Recap | Stats |
| 11/25/2000 | Sat | North Carolina State | Raleigh, N.C. | | L, 32-14
Recap | Stats |
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