Jon Bakero scored the game-winner in the 105th minute off a cross from Justin McMaster for a 1-0 victory.
Wake Forest earned its second straight shutout, taking down Pittsburgh to improve to 2-0 in ACC play.
The Deacs held an opponent without a shot for the first time since 2005, and Ema Twumasi scored twice to lead the offense.
The Demon Deacons opened ACC play with a big road victory, scoring three unanswered goals.
Luis Argudo scored twice, while Jon Bakero and Thomas Menke also found the back of the net.
Check out the one-stop spot to relive Wake Forest's 2016 spring break trip to Madrid and Barcelona from March 4 to March 13.
Jon Bakero scored in the 83rd minute to lift Wake Forest to a 1-0 win over Charlotte in the second round of the NCAA Championship.
Wake Forest topped Notre Dame 2-1 on Oct. 23, 2015, behind a goal in the 87th minute from Jon Bakero. Wake Forest has now won 12 games for the 17th time in program history and is on a nine-game unbeaten streak.
The Demon Deacons improved to 2-0-0 with a commanding 4-1 win over the Friars.
Wake Forest vs. Denver December 11, 2016
Wake Forest took on Denver in the national semifinals on Friday, Dec. 9, 2016.
Memorable images from the Demon Deacons' run to the College Cup
Wake Forest defeated Virginia Tech 2-0 in the Elite Eight to advance to the program's first College Cup since 2009.
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