Senior Mykala Walker came off the bench to grab a season-high tying 10 rebounds and score seven points.
Seton Hall comes into the game with a record of 3-5 overall and 0-2 on the road.
Like Wake Forest, Seton Hall won its first two games of the season and then dropped its next four. All four of those games were away from home.
The Pirates are coming off a 55-42 loss at home to No. 24 South Carolina on Sunday, Dec. 2.
Senior Brittany Morris is the lone Pirate averaging in double-figures at 12.3 points per game. She also leads the team with 11 three-pointers made, 22 assists and is a stellar 27-of-30 from the free throw line.
Sophomore Ka-Deidre Simmons has started all eight games and is second on the team in scoring at 7.6 points per game.
This is the third meeting all-time between the two teams.
Both of the previous two meetings have been played in South Orange, NJ.
Seton Hall won the first meeting on New Years Eve 1990, 71-61. but the Deacons got revenge last season with a 60-44 victory.
Wake Forest will break next week for final exams and then have another week off before opening conference play on Saturday, Dec. 22 at Virginia Tech.
That game is slated for a 2 p.m. tip from Cassell Coliseum.